KPV

KPV is a synthetic tripeptide with the sequence Lys-Pro-Val, corresponding to residues 11 to 13 of alpha-melanocyte-stimulating hormone. It is supplied as a lyophilized powder as a reference compound for laboratory research only.

KPV is a three-residue peptide, Lys-Pro-Val, with the molecular formula C16H30N4O4, a molecular weight of 342.43, and CAS number 67727-97-3.

KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone. Because it reproduces only the final three residues, it is used to test which portion of the parent hormone drives an observed interaction.

Common applications include melanocortin system research, structure-activity relationship studies against the full alpha-MSH sequence, inflammatory signaling pathway models, and peptide fragment comparisons.

SAR work systematically compares related structures to determine which features drive activity. KPV is a standard tool in melanocortin SAR because it isolates a three-residue fragment from a much longer parent sequence.

Several alpha-MSH fragments are studied, differing in which residues they retain. KPV is the shortest of the commonly used ones, which makes it the cleanest test of whether the C-terminal region alone is sufficient for an observed effect.

A three-residue peptide is simple to synthesize, characterize, and interpret. With so few residues there is little ambiguity about which part of the molecule is responsible for an observed interaction.

KPV ships as a lyophilized powder in a sealed vial. It is soluble in bacteriostatic water; consult the certificate of analysis for the solvent recommendations that apply to your lot.

Purity is 99% or greater as verified by HPLC. Lot-specific results are reported on the certificate of analysis accompanying each vial, and that figure is what our purity guarantee is measured against.

Store the lyophilized vial at -20 degrees Celsius, protected from light and moisture. Once reconstituted with bacteriostatic water, refrigerate the solution at 2-8 degrees Celsius and follow your laboratory's established protocols.

Orders leave the same business day when placed before 2pm EST, in an insulated mailer with a phase-change pack. Shipping is free on orders over $150.

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