SELANK

Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP), developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a stabilized analog of tuftsin. It is also designated TP-7, and is supplied as a lyophilized powder as a reference compound for laboratory research only.

Selank is a seven-residue peptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, with the molecular formula C33H57N11O9, a molecular weight of 751.9 g/mol, and CAS number 129954-34-3.

Tuftsin is an endogenous tetrapeptide, Thr-Lys-Pro-Arg, cleaved from the IgG heavy chain. The first four residues of Selank reproduce it exactly. The C-terminal Pro-Gly-Pro motif is the sole structural addition to the native sequence.

The C-terminal glyproline motif slows exopeptidase cleavage. Native tuftsin has a half-life measured in seconds, which makes it impractical for most assay conditions. The added tail is what allows the analog to persist long enough to study.

Research indicates Selank modulates GABA-A receptor subunit expression rather than binding the benzodiazepine site directly. This is an important mechanistic distinction, because it places Selank outside the class of compounds that act as direct allosteric modulators at that site.

Both came from the same institute and share the same stabilizing design, a Pro-Gly-Pro tail added to a short parent sequence. The parents differ: Selank derives from tuftsin, an immune-associated tetrapeptide, while Semax derives from ACTH(4-7). That difference in origin is why Selank carries documented immunomodulatory activity that Semax does not.

Common applications include GABA-A receptor subunit expression studies, BDNF expression in hippocampal tissue, enkephalin-degrading enzyme inhibition assays, monoamine signaling work covering serotonin and dopamine metabolism, and cytokine and IL-6 regulation studies.

Enkephalins are endogenous opioid peptides broken down rapidly by peptidases. Selank is reported to inhibit those enzymes, which raises endogenous enkephalin levels. This is a distinct mechanism from direct receptor binding and is studied separately.

Consistent with its tuftsin origin, published work reports measurable immunomodulatory activity, including effects on cytokine and IL-6 regulation. Because Selank descends from an immune-associated peptide rather than a neurotransmitter or hormone, it occupies an unusual position with both anxiolytic and immunomodulatory activity documented in the same literature.

Reported effects have varied by mouse strain and by administration route. Findings should not be treated as a single fixed effect across models, and strain and route need to be matched when comparing results between published studies.

Purity is 99% or greater as verified by HPLC, with identity confirmed by mass spectrometry. Lot-specific results are reported on the third-party certificate of analysis accompanying each vial.

Store the lyophilized vial at -20 degrees Celsius, protected from light and moisture. Once reconstituted with bacteriostatic water, refrigerate the solution at 2-8 degrees Celsius and follow your laboratory's established protocols.

Orders leave the same business day when placed before 2pm EST, in an insulated mailer with a phase-change pack. Shipping is free on orders over $150.

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