DIHEXA

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$160.00

Dihexa is a small-molecule angiotensin IV analog investigated in neuroscience research for its role in synaptogenesis — the formation of new synaptic connections between neurons. Derived from the angiotensin IV peptide fragment, Dihexa is studied for its activity at the hepatocyte growth factor (HGF) / c-Met receptor system, the signaling pathway through which its neurotrophic activity is proposed to occur. In published in vitro work, Dihexa produced synaptogenic activity at concentrations several orders of magnitude below those required for BDNF (brain-derived neurotrophic factor) in comparable assays. This potency differential is the basis for its research interest as a neurotrophic compound and distinguishes it from peptide-based neurotrophic factors, which show limited blood-brain barrier penetration.

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Purity guarantee. If an independent assay of your lot returns below the purity stated on its certificate, we replace the order or refund it in full — no return shipment required.

Sold for laboratory research and further manufacturing use only. Not a drug, food, cosmetic, or dietary supplement. Not for human or veterinary use, and not for diagnostic or therapeutic purposes. Buyer is responsible for compliance with all applicable regulations.

Lyophilized Research Compound

Technical Overview

Dihexa is a synthetic angiotensin IV–derived peptidomimetic used in laboratory research to investigate hepatocyte growth factor (HGF) and c-Met receptor signaling. The HGF/c-Met pathway is a primary focus in neurotrophic and synaptogenesis research, and Dihexa is studied as a tool compound for probing that signaling axis in vitro and in preclinical models.

Purity: ≥99% by HPLC
CAS Number: 1401708-83-5
Molecular Formula: C₂₅H₃₃N₃O₄
Molecular Weight: 439.55 g/mol
Synonyms: N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide; PNB-0408
Solubility: Soluble in water & bacteriostatic water
Storage: Store lyophilized at −20°C, protected from light & moisture

Frequently Asked Questions

What is Dihexa?

Dihexa is a synthetic angiotensin IV-derived peptidomimetic, also designated PNB-0408 and N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide. It is supplied as a reference compound for laboratory research only.

What is the structure of Dihexa?

Dihexa has the molecular formula C25H33N3O4, a molecular weight of 439.55, and CAS number 1401708-83-5. It is a peptidomimetic rather than a true peptide, built around a modified dipeptide core with hexanoic acid and aminohexanoic amide groups.

What is a peptidomimetic?

A peptidomimetic reproduces the key interaction features of a peptide using a structure that is not a standard amino acid chain. The approach is used to gain stability and membrane permeability that the parent peptide lacks.

What is Dihexa used for in research?

Common applications include hepatocyte growth factor and c-Met receptor signaling studies, synaptogenesis models, neurotrophic pathway investigation, and use as a tool compound for probing the HGF/c-Met axis in vitro.

What is the HGF/c-Met pathway?

Hepatocyte growth factor signals through the c-Met receptor tyrosine kinase. The axis is studied in tissue development, repair, and synapse formation, and Dihexa is used as a tool for probing it.

How does Dihexa relate to angiotensin IV?

Dihexa was derived from angiotensin IV, a fragment of the angiotensin peptide family studied for cognitive and neurotrophic effects separate from blood pressure regulation. Dihexa retains the pharmacophore while gaining stability the native fragment lacks.

What form is Dihexa supplied in?

Unlike the lyophilized vials in the rest of this catalog, Dihexa is supplied as capsules: 5 mg per capsule, 60 capsules, 300 mg total.

What purity is Dihexa supplied at?

Purity is 99% or greater as verified by HPLC. Lot-specific results are reported on the certificate of analysis accompanying each order, and that figure is what our purity guarantee is measured against.

How should Dihexa be stored?

Because Dihexa ships in capsule form rather than as a lyophilized vial, storage differs from the rest of the catalog. Store in a cool, dry place away from direct light, and follow your laboratory's established protocols.

How is Dihexa shipped?

Orders leave the same business day when placed before 2pm EST. Shipping is free on orders over $150.

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