CJC-1295 (NO DAC)

CJC-1295 without DAC is a synthetic 29-amino acid analog of growth hormone-releasing hormone (GHRH). It is also referred to as Modified GRF (1-29), and is supplied as a lyophilized powder as a reference compound for laboratory research only.

DAC stands for Drug Affinity Complex, a maleimide group that binds serum albumin and greatly extends half-life. The version without DAC lacks that group, so it clears far more quickly and is studied for short-duration, pulsatile signaling rather than sustained exposure.

Yes. The two names refer to the same 29-residue modified GHRH analog. Modified GRF (1-29) is the more precise designation, since CJC-1295 originally referred to the DAC-bearing version.

The sequence carries substitutions at positions 2, 8, 15, and 27 relative to unmodified GRF (1-29). These are examined for the resistance to enzymatic degradation they confer, particularly against cleavage by dipeptidyl peptidase-4 at the N-terminus.

Common applications include GHRH receptor binding studies, pulsatile secretagogue signaling models, peptide half-life and degradation comparisons against native GRF (1-29), and combination work with GHS-R agonists.

The two act on separate receptors. CJC-1295 without DAC targets the GHRH receptor while Ipamorelin targets the growth hormone secretagogue receptor. Studying them together is how researchers examine convergent signaling from two distinct upstream inputs.

GRF (1-29) is the first 29 residues of growth hormone-releasing hormone, the shortest fragment retaining full activity at the GHRH receptor. It is the parent sequence that the modified analog is built from and compared against.

It ships as a lyophilized powder in a sealed vial. Consult the certificate of analysis for the solvent recommendations that apply to your lot.

Purity is 99% or greater as verified by HPLC. Lot-specific results are reported on the certificate of analysis accompanying each vial, and that figure is what our purity guarantee is measured against.

Store the lyophilized vial at -20 degrees Celsius, protected from light and moisture. Once reconstituted with bacteriostatic water, refrigerate the solution at 2-8 degrees Celsius and follow your laboratory's established protocols.

Orders leave the same business day when placed before 2pm EST, in an insulated mailer with a phase-change pack. Shipping is free on orders over $150.

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