SEMAGLUTIDE

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Semaglutide is a GLP-1 receptor agonist and the best-studied drug in its class. It mimics glucagon-like peptide-1, a hormone your body releases after eating that signals satiety, slows gastric emptying, and regulates insulin. FDA-approved for type 2 diabetes and obesity, semaglutide produces significant weight loss and cardiovascular risk reduction in large clinical trials.

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Purity guarantee. If an independent assay of your lot returns below the purity stated on its certificate, we replace the order or refund it in full — no return shipment required.

Sold for laboratory research and further manufacturing use only. Not a drug, food, cosmetic, or dietary supplement. Not for human or veterinary use, and not for diagnostic or therapeutic purposes. Buyer is responsible for compliance with all applicable regulations.

Lyophilized Research Compound

Technical Overview

Semaglutide is a synthetic peptide compound supplied for laboratory research involving incretin signaling, GLP-1 receptor pharmacology, and receptor interaction analysis. In research settings, this GLP-1 receptor agonist peptide is used to study receptor-agonist binding profiles, downstream cAMP and insulinotropic signaling responses, and related biochemical mechanisms.

Structurally, semaglutide is a long-acting GLP-1 receptor analog featuring an Aib substitution at position 2 conferring DPP-IV resistance, and a C18 fatty diacid side chain at Lys26 that promotes albumin binding for extended plasma residence. In research models, semaglutide is investigated as a tool compound for probing GLP-1R conformational dynamics and beta-arrestin recruitment.

Investigators use this analog to examine incretin-axis signaling in pancreatic islet preparations, hypothalamic appetite-regulation models, and gastric motility studies. Comparative work alongside native GLP-1 and tirzepatide supports receptor-selectivity and biased-agonism characterization.

This research peptide is synthesized by solid-phase peptide synthesis (SPPS) and purified by reverse-phase HPLC, with batch analytical documentation available for laboratory assays and binding studies. Supplied as lyophilized material for reconstitution per established laboratory protocols, intended as a reference material in controlled research environments.

Purity: ≥99% by HPLC
CAS Number: 910463-68-2
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: 4113.58 g/mol
Amino Acid Count: 31
Sequence: 31-residue GLP-1 receptor agonist analog with Aib at position 2 and Lys26 conjugated to γGlu-(AEEA)2-C18 diacid; C-terminal carboxylate (full sequence per COA).
Synonyms: GLP-1 receptor agonist
Physical Form: Lyophilized powder
Solubility: Soluble in bacteriostatic water; consult the product COA for specific solvent recommendations.
Storage: Store lyophilized at -20°C; protect from light and moisture. Reconstitute with bacteriostatic water; store reconstituted material refrigerated and use per laboratory protocol.

Frequently Asked Questions

What is Semaglutide?

Semaglutide is a synthetic 31-amino acid GLP-1 receptor agonist analog, supplied as a lyophilized powder as a reference compound for laboratory research into incretin signaling and GLP-1 receptor pharmacology.

What is the structure of Semaglutide?

Semaglutide is a 31-residue GLP-1 analog with the molecular formula C187H291N45O59, a molecular weight of 4113.58, and CAS number 910463-68-2. It carries an Aib substitution at position 2 and a C18 fatty diacid conjugated to Lys26 through a gamma-glutamic acid and AEEA spacer.

What does the Aib substitution do?

Alpha-aminoisobutyric acid at position 2 blocks cleavage by dipeptidyl peptidase-4, the enzyme that rapidly degrades native GLP-1. This single substitution is the primary source of the analog's resistance to enzymatic breakdown.

What does the C18 fatty diacid chain do?

The acyl chain at Lys26 promotes reversible albumin binding, which slows clearance and extends plasma residence. Acylation of this kind is the standard approach to lengthening peptide duration in circulation.

What is the difference between Semaglutide and native GLP-1?

Native GLP-1 is degraded within minutes by DPP-4. Semaglutide adds the Aib substitution and the acyl chain to resist that degradation and bind albumin, which is why comparative work between the two is a standard way to study analog design.

What is the difference between Semaglutide and Tirzepatide?

Semaglutide is a single-receptor GLP-1 agonist. Tirzepatide is a dual agonist acting at both the GIP and GLP-1 receptors. The two are compared directly in receptor-selectivity and biased-agonism characterization.

What is biased agonism, and why does it matter for Semaglutide?

Biased agonism describes a ligand that favors one downstream pathway over another at the same receptor, such as G-protein signaling versus beta-arrestin recruitment. Semaglutide is used as a tool compound for probing GLP-1R conformational dynamics and beta-arrestin recruitment specifically.

What is Semaglutide used for in research?

Common applications include receptor-agonist binding profiles, downstream cAMP and insulinotropic signaling, incretin-axis studies in pancreatic islet preparations, hypothalamic appetite-regulation models, and gastric motility studies.

What strengths is Semaglutide available in?

Semaglutide is offered in 5 mg, 10 mg, 20 mg, 30 mg, and 50 mg vials. All are the same compound and purity; the difference is the quantity of lyophilized peptide in the vial.

What purity is Semaglutide supplied at?

Purity is 99% or greater as verified by HPLC. Lot-specific results are reported on the certificate of analysis accompanying each vial, and that figure is what our purity guarantee is measured against.

How should Semaglutide be stored?

Store the lyophilized vial at -20 degrees Celsius, protected from light and moisture. Once reconstituted with bacteriostatic water, refrigerate the solution at 2-8 degrees Celsius and follow your laboratory's established protocols.

How is the vial shipped?

Orders leave the same business day when placed before 2pm EST, in an insulated mailer with a phase-change pack. Shipping is free on orders over $150.

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