CAGRILINTIDE

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Purity Guarantee

$160.00

Cagrilintide is a long-acting synthetic amylin analog studied in laboratory research for amylin and calcitonin receptor (AMY/CTR) interactions in metabolic signaling assays, synthesized by solid-phase peptide synthesis (SPPS), purified by reverse-phase HPLC, and supplied as a lyophilized powder with batch analytical documentation for controlled research use. For research use only — not for human consumption.

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Purity guarantee. If an independent assay of your lot returns below the purity stated on its certificate, we replace the order or refund it in full — no return shipment required.

Sold for laboratory research and further manufacturing use only. Not a drug, food, cosmetic, or dietary supplement. Not for human or veterinary use, and not for diagnostic or therapeutic purposes. Buyer is responsible for compliance with all applicable regulations.

Lyophilized Research Compound

Technical Overview

Cagrilintide is a synthetic 37-amino acid amylin analog acylated with a C20 fatty diacid via a gamma-glutamic acid spacer, a modification that extends plasma half-life relative to native amylin. In laboratory research environments, this amylin analog peptide is studied for its interaction with the amylin (AMY) and calcitonin (CTR) receptor families in metabolic signaling assays. Cagrilintide is synthesized by solid-phase peptide synthesis (SPPS) and purified by reverse-phase HPLC, with batch analytical documentation available for controlled biochemical research.

Purity: ≥99% by HPLC
CAS Number: 1415456-99-3
Molecular Formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
Molecular Weight: 4409.07 g/mol
Amino Acid Count: 37
Physical Form: Lyophilized powder
Solubility: Soluble in bacteriostatic water; consult the product COA for specific solvent recommendations.
Storage: Store lyophilized at -20°C; protect from light and moisture. Reconstitute with bacteriostatic water; refrigerate reconstituted solution at 2-8°C.

Frequently Asked Questions

What is Cagrilintide?

Cagrilintide is a synthetic 37-amino acid amylin analog, acylated with a C20 fatty diacid via a gamma-glutamic acid spacer. It is supplied as a lyophilized powder as a reference compound for laboratory research only.

What is the structure of Cagrilintide?

Cagrilintide is a 37-residue peptide with the molecular formula C194H312N54O59S2, a molecular weight of 4409.07, and CAS number 1415456-99-3. The C20 fatty diacid chain attached through a gamma-glutamic acid spacer is the defining structural feature.

What does the fatty acid chain on Cagrilintide do?

The C20 diacid promotes reversible albumin binding, which slows clearance and extends plasma half-life relative to native amylin. Acylation of this kind is a standard approach to lengthening peptide duration in circulation.

What is amylin?

Amylin is a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells. Native human amylin aggregates readily, which limits its use in laboratory work and is a primary reason stable analogs are studied instead.

What receptors does Cagrilintide act on?

Cagrilintide is studied at the amylin receptor family (AMY1, AMY2, AMY3) and the calcitonin receptor. These receptors are calcitonin receptor cores paired with receptor activity-modifying proteins, which is why selectivity work in this family is comparatively complex.

What is Cagrilintide used for in research?

Common applications include amylin and calcitonin receptor binding assays, metabolic signaling studies, peptide half-life and albumin binding work, and combination studies with incretin analogs.

What is the difference between Cagrilintide and Semaglutide?

Cagrilintide is an amylin analog acting on the amylin and calcitonin receptor family. Semaglutide is a GLP-1 receptor agonist. They act on separate receptor systems, which is why the two are examined together in combination research.

Why is Cagrilintide more stable than native amylin?

Native human amylin is prone to forming insoluble aggregates. Cagrilintide carries sequence substitutions and the acyl chain that reduce aggregation and extend half-life, making it usable in assay conditions where native amylin is not.

What form is Cagrilintide supplied in?

Cagrilintide ships as a lyophilized powder in a sealed vial. Consult the certificate of analysis for the solvent recommendations that apply to your lot.

What purity is Cagrilintide supplied at?

Purity is 99% or greater as verified by HPLC. Lot-specific results are reported on the certificate of analysis accompanying each vial, and that figure is what our purity guarantee is measured against.

How should Cagrilintide be stored?

Store the lyophilized vial at -20 degrees Celsius, protected from light and moisture. Once reconstituted with bacteriostatic water, refrigerate the solution at 2-8 degrees Celsius and follow your laboratory's established protocols.

How is the vial shipped?

Orders leave the same business day when placed before 2pm EST, in an insulated mailer with a phase-change pack. Shipping is free on orders over $150.

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