SEMAX

Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro, first characterized at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s. It is supplied in 10mg lyophilized vials as a reference compound for laboratory research only.

MEHFPGP is the single-letter amino acid code for the sequence: methionine, glutamic acid, histidine, phenylalanine, proline, glycine, proline. It is a shorthand for the same seven residues written as Met-Glu-His-Phe-Pro-Gly-Pro.

Semax is a seven-residue peptide with the molecular formula C37H51N9O10S, a molecular weight of approximately 813.9 g/mol, and CAS number 80714-61-0. The sulfur atom comes from the N-terminal methionine.

Both descriptions appear in the literature, and they describe the same molecule. ACTH(4-10) is Met-Glu-His-Phe-Arg-Trp-Gly. Semax keeps the first four of those residues and replaces the last three with Pro-Gly-Pro. So it is an ACTH(4-10) analog by position and length, and equivalently the ACTH(4-7) fragment carrying a Pro-Gly-Pro extension. Neither description is wrong; they emphasize different halves of the same substitution.

The residues responsible for stimulating cortisol release lie outside the fragment Semax retains. By keeping only positions 4 through 7 and substituting synthetic residues for the rest, the analog separates the neuroactive properties of the region from the endocrine activity of the parent hormone. That separation is the entire reason the fragment is studied rather than ACTH itself.

Pro-Gly-Pro is a glyproline motif attached at the C-terminus. It slows exopeptidase cleavage, substantially increasing resistance to enzymatic degradation compared with the bare ACTH fragment, which would not survive most assay conditions long enough to study.

Common applications include BDNF and NGF expression studies, dopaminergic and serotonergic signaling work, neuronal survival in cerebral ischemia models, attention and memory consolidation paradigms, and neurotrophin gene transcription analysis.

Both are neurotrophins, but they act through different receptors and support different neuron populations. BDNF signals primarily through TrkB and is associated with synaptic plasticity; NGF signals through TrkA and is associated with cholinergic and sensory neurons. Semax literature reports effects on both, which is why they are measured separately.

Ischemia models test neuronal survival under oxygen and glucose deprivation, a setting where neurotrophin expression becomes directly measurable against a clear endpoint. Published work reports that both Semax and its Pro-Gly-Pro fragment upregulate transcription of neurotrophin and neurotrophin-receptor genes in these models.

The peptide is identical. This product is a 10mg lyophilized vial, leaving solvent and preparation to you. The nasal spray is supplied as a research kit with a mist applicator. Choose the vial when your protocol specifies its own reconstitution.

Purity is 99% or greater as verified by HPLC. Analytical documentation accompanies every order, and that figure is what our purity guarantee is measured against.

Store the lyophilized vial at -20 degrees Celsius, protected from light and moisture. Once reconstituted with bacteriostatic water, refrigerate the solution at 2-8 degrees Celsius and follow your laboratory's established protocols.

Orders leave the same business day when placed before 2pm EST, in an insulated mailer with a phase-change pack. Shipping is free on orders over $150.

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