PT-141

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PT-141 (bremelanotide) is a synthetic cyclic heptapeptide supplied in 10mg vials for laboratory research into melanocortin signaling and central neuroendocrine pathways. Research applications include receptor interaction analysis and controlled experimental investigation. In research settings, PT-141 is most commonly used to study MC3R and MC4R receptor binding, downstream cAMP signaling in hypothalamic models, and related biochemical mechanisms. Structurally, PT-141 is an analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It features a side-chain lactam bridge between Asp and Lys, N-terminal acetylation, and the incorporation of norleucine and D-phenylalanine for protease resistance. PT-141 is a non-selective agonist at MC1R, MC3R, MC4R, and MC5R, with preferential activity at MC3R and MC4R.

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Sold for laboratory research and further manufacturing use only. Not a drug, food, cosmetic, or dietary supplement. Not for human or veterinary use, and not for diagnostic or therapeutic purposes. Buyer is responsible for compliance with all applicable regulations.

Lyophilized Research Compound

Technical Overview

Researchers use PT-141 to investigate central melanocortin signaling, sexual-behavior circuits in rodent models, and receptor-selectivity comparisons against alpha-MSH and NDP-MSH. Its protease-resistant structure makes it a stable reference compound in melanocortin receptor pharmacology, where native alpha-MSH degrades too quickly for many assay conditions.

PT-141 is synthesized by established solid-phase peptide synthesis (SPPS) and purified by reversed-phase HPLC to analytical purity suitable for binding studies, laboratory assays, and analytical applications. Supplied as lyophilized powder for reconstitution per established laboratory protocols, and intended as a reference material in controlled research environments.

Purity: ≥99% by HPLC
CAS Number: 189691-06-3
Molecular Formula: C₅₀H₆₈N₁₄O₁₀
Molecular Weight: 1025.16 g/mol
Amino Acid Count: 7
Sequence: Cyclic heptapeptide Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH with a side-chain lactam bridge between Asp and Lys; N-terminal acetylation and incorporation of norleucine and D-Phe confer protease resistance (full sequence per COA).
Synonyms: Bremelanotide
Physical Form: Lyophilized powder
Solubility: Soluble in bacteriostatic water; consult the product COA for specific solvent recommendations.
Storage: Store lyophilized at -20°C; protect from light and moisture. Reconstitute with bacteriostatic water; store reconstituted material refrigerated and use per laboratory protocol.

Frequently Asked Questions

What is PT-141?

PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It is supplied as a reference compound for laboratory research into melanocortin receptor signaling and central neuroendocrine pathways.

What is PT-141 also called?

PT-141 is also known as bremelanotide. Both names refer to the same cyclic heptapeptide, CAS 189691-06-3.

What receptors does PT-141 bind?

PT-141 is a non-selective melanocortin agonist with activity at MC1R, MC3R, MC4R, and MC5R. It shows preferential activity at MC3R and MC4R, and negligible activity at MC2R.

How does PT-141 work at the receptor level?

Melanocortin receptors are Gs-coupled GPCRs. PT-141 binding stimulates adenylyl cyclase and raises intracellular cAMP, which is the primary readout used in melanocortin signaling assays.

What is PT-141 used for in research?

Common applications include MC3R and MC4R binding studies, downstream cAMP signaling in hypothalamic models, central melanocortin pathway investigation, sexual-behavior circuits in rodent models, and receptor-selectivity comparisons against alpha-MSH and NDP-MSH.

What is the molecular structure of PT-141?

PT-141 is a cyclic heptapeptide with the molecular formula C50H68N14O10 and a molecular weight of 1025.16. It carries a side-chain lactam bridge between aspartic acid and lysine, N-terminal acetylation, and norleucine and D-phenylalanine substitutions.

Why is PT-141 protease resistant?

The norleucine and D-phenylalanine substitutions and the Asp-Lys lactam bridge resist enzymatic degradation. Native alpha-MSH degrades rapidly under many assay conditions, so PT-141 serves as a more stable reference compound for extended experiments.

What is the difference between PT-141 and Melanotan II?

PT-141 is the C-terminal deamidated metabolite of Melanotan II. Both act on melanocortin receptors, but their receptor activity profiles differ, with Melanotan II showing stronger MC1R activity associated with pigmentation pathways.

What is the difference between PT-141 and alpha-MSH?

Alpha-MSH is the endogenous melanocortin peptide. PT-141 is a synthetic analog engineered for protease resistance and altered receptor selectivity, which makes it more stable than alpha-MSH under typical assay conditions.

What is the difference between PT-141 and NDP-MSH?

NDP-MSH (afamelanotide) is a linear alpha-MSH analog, while PT-141 is cyclic. Both are used as melanocortin reference compounds and are frequently compared in receptor-selectivity studies.

How is PT-141 manufactured?

By solid-phase peptide synthesis (SPPS), followed by purification via reversed-phase high-performance liquid chromatography (RP-HPLC).

What purity is PT-141 supplied at?

Purity is 99% or greater as verified by HPLC. Lot-specific results are reported on the certificate of analysis accompanying each vial.

How should PT-141 be stored?

Store the lyophilized peptide at -20 degrees Celsius, protected from light and moisture. Once reconstituted, refrigerated storage at 2-8 degrees Celsius is standard, with limited stability. Follow your laboratory's established protocols.

Melanotan 2 is a synthetic cyclic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH), and it is chemically…

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