SEMAX NASAL SPRAY

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Purity Guarantee

$80.00

Semax nasal spray delivers a synthetic heptapeptide originally developed in Russia in the 1980s at the Institute of Molecular Genetics, Russian Academy of Sciences, for stroke recovery and cognitive research. The molecule is built from a short fragment of ACTH the adrenocorticotropic hormone sequence ACTH(4-7) with a Pro-Gly-Pro tail attached at the C-terminus. That tail is the functional addition: it shields the peptide from rapid enzymatic breakdown and extends how long it stays intact, which the parent fragment on its own does not do. Although Semax is derived from a stress hormone, it does not carry the hormonal activity of ACTH. It does not stimulate the adrenal cortex or drive cortisol release, which is what separates it from the hormone it was modeled on.

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Purity guarantee. If an independent assay of your lot returns below the purity stated on its certificate, we replace the order or refund it in full — no return shipment required.

Sold for laboratory research and further manufacturing use only. Not a drug, food, cosmetic, or dietary supplement. Not for human or veterinary use, and not for diagnostic or therapeutic purposes. Buyer is responsible for compliance with all applicable regulations.

Lyophilized Research Compound

Technical Overview

In rodent studies, Semax increases expression of BDNF (brain-derived neurotrophic factor) and its TrkB receptor in the hippocampus. BDNF is the principal growth factor governing neuronal survival, differentiation, and synaptic plasticity. Animal research has also shown Semax activating dopaminergic and serotonergic brain systems, and in cerebral ischemia models both Semax and its Pro-Gly-Pro fragment upregulate transcription of neurotrophin and neurotrophin-receptor genes.

Purity: ≥99% by HPLC
CAS Number: 80714-61-0
Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: 813.93 g/mol
Amino Acid Count: 7
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Synonyms: ACTH(4-7) analogue
Physical Form: Lyophilized powder
Solubility: Soluble in bacteriostatic water; consult the product COA for specific solvent recommendations.
Storage: Store lyophilized at -20°C; protect from light and moisture. Reconstitute with bacteriostatic water; refrigerate reconstituted solution at 2-8°C.

Frequently Asked Questions

What is Semax?

Semax is a synthetic heptapeptide analog of ACTH(4-7), extended with a C-terminal Pro-Gly-Pro sequence. It is supplied here as a research kit for laboratory use only.

What is the structure of Semax?

Semax is a seven-residue peptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. The molecular formula is C37H51N9O10S, the molecular weight is 813.93, and the CAS number is 80714-61-0.

What does the Pro-Gly-Pro extension do?

The C-terminal Pro-Gly-Pro tripeptide protects the sequence against enzymatic degradation. The unmodified ACTH(4-7) fragment is cleared far more rapidly, so this extension is what makes the analog usable in extended experiments.

How does Semax relate to ACTH?

Semax reproduces residues 4 to 7 of adrenocorticotropic hormone with the stabilizing extension added. Because it retains only that short fragment, it lacks the corticotropic activity of the full hormone, which is central to why it is studied.

What is Semax used for in research?

Common applications include BDNF and TrkB expression studies in hippocampal models, dopaminergic and serotonergic system activation, neurotrophin gene transcription work, and cerebral ischemia models.

What does the BDNF research on Semax show?

In rodent studies, Semax increases expression of brain-derived neurotrophic factor and its TrkB receptor in the hippocampus. BDNF governs neuronal survival, differentiation, and synaptic plasticity, which makes this the most-reported readout in the Semax literature.

What is the Pro-Gly-Pro fragment studied separately for?

In cerebral ischemia models, both Semax and its Pro-Gly-Pro fragment upregulate transcription of neurotrophin and neurotrophin-receptor genes. Testing the fragment alone is how researchers determine whether the extension is merely protective or independently active.

What is included in the Semax nasal spray kit?

The kit contains one 10 mg Semax vial and one mist applicator. It is supplied as a research kit rather than a bare vial.

What form is the Semax in this kit supplied in?

The peptide ships as a lyophilized powder in a sealed vial, packaged alongside the applicator. Consult the certificate of analysis for the solvent recommendations that apply to your lot.

What purity is Semax supplied at?

Purity is 99% or greater as verified by HPLC. Lot-specific results are reported on the certificate of analysis accompanying each vial, and that figure is what our purity guarantee is measured against.

How should the Semax kit be stored?

Store the lyophilized vial at -20 degrees Celsius, protected from light and moisture. Once reconstituted, refrigerate at 2-8 degrees Celsius and follow your laboratory's established protocols.

How is the kit shipped?

Orders leave the same business day when placed before 2pm EST, in an insulated mailer with a phase-change pack. Shipping is free on orders over $150.

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