SELANK + SEMAX NASAL SPRAY

It is a prepared research solution containing both Selank and Semax in saline, supplied in nasal spray format as a reference material for laboratory research only. It differs from the rest of this catalog in that it arrives as a solution rather than as dry powder awaiting reconstitution.

Two heptapeptides. Semax is Met-Glu-His-Phe-Pro-Gly-Pro, formula C37H51N9O10S, 813.93 g/mol, CAS 80714-61-0. Selank is Thr-Lys-Pro-Arg-Pro-Gly-Pro, formula C33H57N11O9, 751.87 g/mol, CAS 129954-34-3. Both are seven residues and both end in the same three, but their first four residues come from unrelated parent molecules.

The peptides are identical; the preparation is not. The vial blend arrives as dry lyophilized powder, leaving the choice of solvent, concentration, and preparation timing to you. This product arrives already in saline. Pick the vial blend when your protocol specifies its own reconstitution; pick this one when a prepared solution is what the protocol calls for.

Separate sprays let you vary each peptide independently, apply them on different schedules, or run one as a control against the other. This combined preparation fixes both into a single solution at a set ratio. It exists for protocols that call for the two together and no separate handling of either.

Because their published mechanisms sit in adjacent systems rather than competing ones. Combining them into one solution removes a variable from co-investigation studies, since both components experience identical handling, storage history, and solution age.

The blood-brain barrier excludes most peptides from the central nervous system. Intranasal routes are studied because the olfactory and trigeminal pathways offer access that bypasses it. Published protocols for both compounds have examined intranasal alongside subcutaneous administration, and the comparison between the two routes is itself a research question.

It describes the movement of a compound from the nasal cavity to the central nervous system along the olfactory and trigeminal nerve pathways, rather than through systemic circulation. It is an active area of study in peptide delivery research precisely because so few peptides cross the blood-brain barrier on their own.

Saline is isotonic, matching the osmolarity of nasal tissue, which makes it the conventional vehicle for intranasal preparations in published protocols. Bacteriostatic water, the standard reconstitution solvent for the lyophilized products in this catalog, is not isotonic. The peptides are soluble in both.

Yes. Lyophilized peptides are stable for extended periods at -20 degrees Celsius because water has been removed. Any peptide already in solution begins its usable life on preparation, and hydrolysis and aggregation proceed from that point. Plan the working life of this preparation accordingly and follow your laboratory protocols.

Both carry a C-terminal Pro-Gly-Pro motif, a glyproline tail that resists exopeptidase cleavage. That modification was introduced to protect against enzymatic degradation, which is a separate matter from chemical stability in a stored solution. The Pro-Gly-Pro tail does not substitute for correct storage.

Semax appears in work on BDNF and NGF expression, dopaminergic and serotonergic modulation, attention and memory consolidation, and post-ischemic neuroprotection. Selank appears in work on GABAergic and serotonergic signaling, cytokine and interferon expression, enkephalin degradation kinetics, and gastroprotective activity. Studies covering both have examined learning and memory paradigms, anxiety-related behavior, nociceptive and inflammatory processes, and peripheral nerve regeneration.

Each component is 99% or greater as verified by HPLC. Lot-specific results for both peptides are reported on the certificate of analysis accompanying the product.

Store at -20 degrees Celsius, protected from light and moisture. Because this product arrives as a solution rather than as dry powder, storage discipline matters more here than for the lyophilized vials elsewhere in the catalog.

Orders leave the same business day when placed before 2pm EST, in an insulated mailer with a phase-change pack. Shipping is free on orders over $150.

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